Controlled protein release from microcapsules with composite shells using high frequency ultrasound—potential for in vivo medical use


Pavlov, A.M. , Saez, V. , Cobley, A. , Graves, J. , Sukhorukov, G.B. and Mason, T.J. (2011) Controlled protein release from microcapsules with composite shells using high frequency ultrasound—potential for in vivo medical use. Soft Matter, volume 7 (9): 4341–4347


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Abstract

The possibility of protein release from polymeric microcapsules by means of low-power (up to a maximum of 3.2 W) high-frequency (850 kHz) ultrasound was studied. The release efficiency using these ultrasonic parameters that are close to those currently used in medical diagnostic and ultrasound treatment was compared to that achieved with a conventional 20 kHz 70 W ultrasonic probe. Microcapsules were made by polyelectrolyte multilayer assembly on 3–5 mm calcium carbonate particles with co-precipitated fluorescently labelled protein. Ultrasound induced protein release was monitored by supernatant fluorescence increase after sonication. The release efficiency is improved by the presence of gold nanoparticles in the microcapsule shell. The amount of gold nanoparticles in the shell was found to play an important role in release efficiency. The irradiation was carried out at several intensities and exposure times and evidence of microcapsule rupture after treatment was obtained by confocal and scanning electron microscopy.



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Item TypeArticle
TitleControlled protein release from microcapsules with composite shells using high frequency ultrasound—potential for in vivo medical use
AuthorsPavlov, A.M.
Saez, V.
Cobley, A.
Graves, J.
Sukhorukov, G.B.
Mason, T.J. (profile-link for Mason, T.J.)
Departments Faculty of Health and Life Sciences
Faculty of Health and Life Sciences/Biomolecular and Sports Sciences
Faculty of Health and Life Sciences/Centre for Sonochemistry
Additional InformationThe full text is not available from the repository.
Identifiers
DOI10.1039/c0sm01536a
Publisher statementpost print with 12 month embargo, unless author chose open access publishing option (published version, no embargo).
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Deposited on 30-Jul-2012 in Research - Coventry.
Last modified on 19-Sep-2016

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