Effects of physiological caffeine concentration on isolated skeletal muscle force, power and fatigue resistance


Tallis, J. (2013) Effects of physiological caffeine concentration on isolated skeletal muscle force, power and fatigue resistance. Unpublished PhD Thesis. Coventry: Coventry University


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Abstract

Caffeine is the most widely consumed socially acceptable drug in the world and is commonly used for its ergogenic properties with demonstrated performance enhancing effects in endurance, power and strength based activities. Despite a wealth of evidence concluding a caffeine induced performance benefit, the direct effects of the drug on peripheral physiological processes have not been fully examined. Early works showed high dose caffeine has direct force potentiating effect on skeletal muscle, a notion that has only recently been confirmed by James et al. (2005) to also occur at a maximal human physiological concentration (70µM). The present research, using mouse muscle as a model for mammalian muscle in general, provides an in-depth assessment of the direct effect of physiological concentrations of caffeine on isolated skeletal muscle performance. This research uniquely: quantifies the dose response relationship; assesses the effects of caffeine on maximal and sub maximal muscle power output and fatigue; looks at the relationship between muscles with different fiber type compositions. As high concentrations of caffeine and taurine are a constituent of many energy drinks, the suggested interaction of these ingredients to further potentiate muscle mechanical performance was also assessed. The study further examines how mammalian muscle mechanical properties change over an age range of development to aged, and how this differs between muscles with predominantly different anatomical locations and functions. In light of this the age related direct effect of physiological concentrations of caffeine was assessed in order to examine whether the ergogenic benefit changed with age. The present results demonstrate a direct muscle performance enhancing effect of physiological concentrations of caffeine that is likely to promote greater benefit on long duration endurance based activities. Furthermore, the present study demonstrates that there is no direct effect of physiological concentrations of taurine and no further performance enhancing benefit when combined with caffeine. Finally this research uniquely highlights the muscle specific age related changes in mechanical performance and further indicates that the direct effect of caffeine changes with age.



Details

Item TypeThesis (PhD)
TitleEffects of physiological caffeine concentration on isolated skeletal muscle force, power and fatigue resistance
Authors Tallis, J. (profile-link for ) http://orcid.org/0000-0001-8904-2693
Uncontrolled Keywordssport performance, muscle strength, caffeine, taurine, energy drinks, physiological effects
Library of Congress
Subject Headings
Muscle strength
Caffeine -- Physiological effect
Sports -- Physiological aspects
Exercise -- Physiological aspects
Departments Faculty of Health and Life Sciences/Biomolecular and Sports Sciences
Faculty of Health and Life Sciences
Additional InformationSome materials have been removed from this thesis due to third party copyright. Pages where material has been removed are clearly marked in the electronic version. The unabridged version of the thesis can be viewed at the Lanchester Library, Coventry University.
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Deposited on 23-Dec-2014 in Research - Coventry.
Last modified on 13-May-2016

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